Deprecated_IonRole

Role ion plays in cellular mechanism, e.g. ion passes through the channel (Na, K), or the 
concentration of the ion is a factor in the rate equations of gating, or the mechanism alters 
the concentration of this ion. This greatly simplifies the number of roles an ion can play 
in the channel, but these options cover the majority of cases currently being modelled. Note: the term subtance is used as 
this formalism can also be used for other chemicals which may be transmitted, modulate channels, etc.

Simple Type Information

Used By

Source

<xs:simpleType name="Deprecated_IonRole">
  <xs:annotation>
    <xs:documentation>Role ion plays in cellular mechanism, e.g. ion passes through the channel (Na, K), or the concentration of the ion is a factor in the rate equations of gating, or the mechanism alters the concentration of this ion. This greatly simplifies the number of roles an ion can play in the channel, but these options cover the majority of cases currently being modelled. Note: the term subtance is used as this formalism can also be used for other chemicals which may be transmitted, modulate channels, etc.</xs:documentation>
  </xs:annotation>
  <xs:restriction base="xs:string">
    <xs:enumeration value="PermeatedSubstance">
      <xs:annotation>
        <xs:documentation>Ion passes through the channel, e.g. Na ions permeate through an "Na Channel"</xs:documentation>
      </xs:annotation>
    </xs:enumeration>
    <xs:enumeration value="PermeatedSubstanceFixedRevPot">
      <xs:annotation>
        <xs:documentation>WARNING: Ion passes through the channel, but the reversal potential of the ion isn't altered. This case is to cope with existing models which (rightly or wrongly) have calcium channels which lead to a calcium current, but which have a fixed reversal potential (Traub et. al 2003 CaL, Maex, De Schutter 1998 CaHVA). Be sure that this is the correct intended behaviour of the channel before using this IonRole.</xs:documentation>
      </xs:annotation>
    </xs:enumeration>
    <xs:enumeration value="ModulatingSubstance">
      <xs:annotation>
        <xs:documentation>Concentration of ion/substance modulates dynamics/rate equations of channel, e.g. Ca dependent K channel, K permeates, but the rate is dependent on concentration of internal Ca</xs:documentation>
      </xs:annotation>
    </xs:enumeration>
    <xs:enumeration value="SignallingSubstance">
      <xs:annotation>
        <xs:documentation>Ion/substance is involved in internal signalling in the cell and the mechanism can alter its concentration, e.g. exponentially decaying Ca pool</xs:documentation>
      </xs:annotation>
    </xs:enumeration>
  </xs:restriction>
</xs:simpleType>