PDBx:pdbx_reference_molecule_detailsType

<xsd:complexType name="pdbx_reference_molecule_detailsType">
  <xsd:annotation>
    <xsd:documentation xml:lang="en">Data items in the PDBX_REFERENCE_MOLECULE_DETAILS category records textual details about small polymer molecules. Example: 1 Actinomycin <PDBx:pdbx_reference_molecule_detailsCategory> <PDBx:pdbx_reference_molecule_details family_prd_id="FAM_000001" ordinal="1"> <PDBx:prd_id>PRD_000001</PDBx:prd_id> <PDBx:source>Wikipedia</PDBx:source> <PDBx:text> Actinomycin D is primarily used as an investigative tool in cell biology to inhibit transcription. It does this by binding DNA at the transcription initiation complex and preventing elongation by RNA polymerase. Because it can bind DNA duplexes, it can also interfere with DNA replication, although other chemicals such as hydroxyurea are better suited for use in the laboratory as inhibitors of DNA synthesis.</PDBx:text> </PDBx:pdbx_reference_molecule_details> <PDBx:pdbx_reference_molecule_details family_prd_id="FAM_000001" ordinal="2"> <PDBx:prd_id>PRD_000001</PDBx:prd_id> <PDBx:source>DrugBank</PDBx:source> <PDBx:text> A compound composed of a two cyclic peptides attached to a phenoxazine that is derived from streptomyces parvullus. It binds to DNA and inhibits RNA synthesis (transcription), with chain elongation more sensitive than initiation, termination, or release. As a result of impaired mRNA production, protein synthesis also declines after dactinomycin therapy.</PDBx:text> </PDBx:pdbx_reference_molecule_details> <PDBx:pdbx_reference_molecule_details family_prd_id="FAM_000001" ordinal="3"> <PDBx:prd_id>PRD_000003</PDBx:prd_id> <PDBx:source>DOI</PDBx:source> <PDBx:source_id>DOI:10.1016/S0960-894X(98)00345-X</PDBx:source_id> <PDBx:text> Actinomycin D, C2 and VII, cyclic peptides, inhibit Grb2 SH2 domain association with a phosphotyrosine containing peptide derived from the Shc protein (pTyr317). Actinomycins are the first examples of nonphosphorylated natural ligands of SH2 domain.</PDBx:text> </PDBx:pdbx_reference_molecule_details> </PDBx:pdbx_reference_molecule_detailsCategory></xsd:documentation>
  </xsd:annotation>
  <xsd:sequence>
    <xsd:element name="pdbx_reference_molecule_details" minOccurs="0" maxOccurs="unbounded">
      <xsd:complexType>
        <xsd:all>
          <xsd:element name="prd_id" minOccurs="0" maxOccurs="1" nillable="true" type="xsd:string">
            <xsd:annotation>
              <xsd:documentation xml:lang="en">The value of attribute prd_id in category pdbx_reference_molecule_details is a reference to attribute prd_id in category pdbx_reference_molecule in the PDBX_REFERENCE_MOLECULE category.</xsd:documentation>
            </xsd:annotation>
          </xsd:element>
          <xsd:element name="source" minOccurs="0" maxOccurs="1" nillable="true" type="xsd:string">
            <xsd:annotation>
              <xsd:documentation xml:lang="en">A data source of this information (e.g. PubMed, Merck Index)</xsd:documentation>
            </xsd:annotation>
          </xsd:element>
          <xsd:element name="source_id" minOccurs="0" maxOccurs="1" nillable="true" type="xsd:string">
            <xsd:annotation>
              <xsd:documentation xml:lang="en">A identifier within the data source for this information.</xsd:documentation>
            </xsd:annotation>
          </xsd:element>
          <xsd:element name="text" minOccurs="1" maxOccurs="1" type="xsd:string">
            <xsd:annotation>
              <xsd:documentation xml:lang="en">The text of the description of special aspects of the entity.</xsd:documentation>
            </xsd:annotation>
          </xsd:element>
        </xsd:all>
        <xsd:attribute name="family_prd_id" use="required" type="xsd:string">
          <xsd:annotation>
            <xsd:documentation xml:lang="en">The value of attribute family_prd_id in category pdbx_reference_molecule_details is a reference to attribute family_prd_id' in category pdbx_reference_molecule_list in category PDBX_REFERENCE_MOLECULE_FAMILY.</xsd:documentation>
          </xsd:annotation>
        </xsd:attribute>
        <xsd:attribute name="ordinal" use="required" type="xsd:integer">
          <xsd:annotation>
            <xsd:documentation xml:lang="en">The value of attribute ordinal in category pdbx_reference_molecule_details is an ordinal that distinguishes each descriptive text for this entity.</xsd:documentation>
          </xsd:annotation>
        </xsd:attribute>
      </xsd:complexType>
    </xsd:element>
  </xsd:sequence>
</xsd:complexType>