<xsd:complexType name="entity_src_genType">
<xsd:annotation>
<xsd:documentation xml:lang="en">Data items in the ENTITY_SRC_GEN category record details of the source from which the entity was obtained in cases where the source was genetically manipulated. The following are treated separately: items pertaining to the tissue from which the gene was obtained, items pertaining to the host organism for gene expression and items pertaining to the actual producing organism (plasmid). Example 1 - based on PDB entry 5HVP and laboratory records for the structure corresponding to PDB entry 5HVP. <PDBx:entity_src_genCategory> <PDBx:entity_src_gen entity_id="1" pdbx_src_id="1"> <PDBx:gene_src_common_name>HIV-1</PDBx:gene_src_common_name> <PDBx:gene_src_strain>NY-5</PDBx:gene_src_strain> <PDBx:host_org_common_name>bacteria</PDBx:host_org_common_name> <PDBx:host_org_genus>Escherichia</PDBx:host_org_genus> <PDBx:host_org_species>coli</PDBx:host_org_species> <PDBx:plasmid_name>pB322</PDBx:plasmid_name> </PDBx:entity_src_gen> </PDBx:entity_src_genCategory></xsd:documentation>
</xsd:annotation>
<xsd:sequence>
<xsd:element name="entity_src_gen" minOccurs="0" maxOccurs="unbounded">
<xsd:complexType>
<xsd:all>
<xsd:element name="expression_system_id" minOccurs="0" maxOccurs="1" nillable="true" type="xsd:string">
<xsd:annotation>
<xsd:documentation xml:lang="en">A unique identifier for the expression system. This should be extracted from a local list of expression systems.</xsd:documentation>
</xsd:annotation>
</xsd:element>
<xsd:element name="gene_src_common_name" minOccurs="0" maxOccurs="1" nillable="true" type="xsd:string">
<xsd:annotation>
<xsd:documentation xml:lang="en">The common name of the natural organism from which the gene was obtained. man yeast bacteria</xsd:documentation>
</xsd:annotation>
</xsd:element>
<xsd:element name="gene_src_details" minOccurs="0" maxOccurs="1" nillable="true" type="xsd:string">
<xsd:annotation>
<xsd:documentation xml:lang="en">A description of special aspects of the natural organism from which the gene was obtained.</xsd:documentation>
</xsd:annotation>
</xsd:element>
<xsd:element name="gene_src_dev_stage" minOccurs="0" maxOccurs="1" nillable="true" type="xsd:string">
<xsd:annotation>
<xsd:documentation xml:lang="en">A string to indicate the life-cycle or cell development cycle in which the gene is expressed and the mature protein is active.</xsd:documentation>
</xsd:annotation>
</xsd:element>
<xsd:element name="gene_src_genus" minOccurs="0" maxOccurs="1" nillable="true" type="xsd:string">
<xsd:annotation>
<xsd:documentation xml:lang="en">The genus of the natural organism from which the gene was obtained. Homo Saccharomyces Escherichia</xsd:documentation>
</xsd:annotation>
</xsd:element>
<xsd:element name="gene_src_species" minOccurs="0" maxOccurs="1" nillable="true" type="xsd:string">
<xsd:annotation>
<xsd:documentation xml:lang="en">The species of the natural organism from which the gene was obtained. sapiens cerevisiae coli</xsd:documentation>
</xsd:annotation>
</xsd:element>
<xsd:element name="gene_src_strain" minOccurs="0" maxOccurs="1" nillable="true" type="xsd:string">
<xsd:annotation>
<xsd:documentation xml:lang="en">The strain of the natural organism from which the gene was obtained, if relevant. DH5a BMH 71-18</xsd:documentation>
</xsd:annotation>
</xsd:element>
<xsd:element name="gene_src_tissue" minOccurs="0" maxOccurs="1" nillable="true" type="xsd:string">
<xsd:annotation>
<xsd:documentation xml:lang="en">The tissue of the natural organism from which the gene was obtained. heart liver eye lens</xsd:documentation>
</xsd:annotation>
</xsd:element>
<xsd:element name="gene_src_tissue_fraction" minOccurs="0" maxOccurs="1" nillable="true" type="xsd:string">
<xsd:annotation>
<xsd:documentation xml:lang="en">The subcellular fraction of the tissue of the natural organism from which the gene was obtained. mitochondria nucleus membrane</xsd:documentation>
</xsd:annotation>
</xsd:element>
<xsd:element name="host_org_common_name" minOccurs="0" maxOccurs="1" nillable="true" type="xsd:string">
<xsd:annotation>
<xsd:documentation xml:lang="en">The common name of the organism that served as host for the production of the entity. Where full details of the protein production are available it would be expected that this item be derived from attribute host_org_common_name in category entity_src_gen_express or via attribute host_org_tax_id in category entity_src_gen_express yeast bacteria</xsd:documentation>
</xsd:annotation>
</xsd:element>
<xsd:element name="host_org_details" minOccurs="0" maxOccurs="1" nillable="true" type="xsd:string">
<xsd:annotation>
<xsd:documentation xml:lang="en">A description of special aspects of the organism that served as host for the production of the entity. Where full details of the protein production are available it would be expected that this item would derived from attribute host_org_details in category entity_src_gen_express</xsd:documentation>
</xsd:annotation>
</xsd:element>
<xsd:element name="host_org_genus" minOccurs="0" maxOccurs="1" nillable="true" type="xsd:string">
<xsd:annotation>
<xsd:documentation xml:lang="en">The genus of the organism that served as host for the production of the entity. Saccharomyces Escherichia</xsd:documentation>
</xsd:annotation>
</xsd:element>
<xsd:element name="host_org_species" minOccurs="0" maxOccurs="1" nillable="true" type="xsd:string">
<xsd:annotation>
<xsd:documentation xml:lang="en">The species of the organism that served as host for the production of the entity. cerevisiae coli</xsd:documentation>
</xsd:annotation>
</xsd:element>
<xsd:element name="host_org_strain" minOccurs="0" maxOccurs="1" nillable="true" type="xsd:string">
<xsd:annotation>
<xsd:documentation xml:lang="en">The strain of the organism in which the entity was expressed. Where full details of the protein production are available it would be expected that this item be derived from attribute host_org_strain in category entity_src_gen_express or via attribute host_org_tax_id in category entity_src_gen_express DH5a BMH 71-18</xsd:documentation>
</xsd:annotation>
</xsd:element>
<xsd:element name="pdbx_alt_source_flag" minOccurs="0" maxOccurs="1" nillable="true">
<xsd:annotation>
<xsd:documentation xml:lang="en">This data item identifies cases in which an alternative source modeled.</xsd:documentation>
</xsd:annotation>
<xsd:simpleType>
<xsd:restriction base="xsd:string">
<xsd:enumeration value="sample"/>
<xsd:enumeration value="model"/>
</xsd:restriction>
</xsd:simpleType>
</xsd:element>
<xsd:element name="pdbx_beg_seq_num" minOccurs="0" maxOccurs="1" nillable="true" type="xsd:integer">
<xsd:annotation>
<xsd:documentation xml:lang="en">The beginning polymer sequence position for the polymer section corresponding to this source. A reference to the sequence position in the entity_poly category.</xsd:documentation>
</xsd:annotation>
</xsd:element>
<xsd:element name="pdbx_description" minOccurs="0" maxOccurs="1" nillable="true" type="xsd:string">
<xsd:annotation>
<xsd:documentation xml:lang="en">Information on the source which is not given elsewhere.</xsd:documentation>
</xsd:annotation>
</xsd:element>
<xsd:element name="pdbx_end_seq_num" minOccurs="0" maxOccurs="1" nillable="true" type="xsd:integer">
<xsd:annotation>
<xsd:documentation xml:lang="en">The ending polymer sequence position for the polymer section corresponding to this source. A reference to the sequence position in the entity_poly category.</xsd:documentation>
</xsd:annotation>
</xsd:element>
<xsd:element name="pdbx_gene_src_atcc" minOccurs="0" maxOccurs="1" nillable="true" type="xsd:string">
<xsd:annotation>
<xsd:documentation xml:lang="en">American Type Culture Collection tissue culture number. 6051</xsd:documentation>
</xsd:annotation>
</xsd:element>
<xsd:element name="pdbx_gene_src_cell" minOccurs="0" maxOccurs="1" nillable="true" type="xsd:string">
<xsd:annotation>
<xsd:documentation xml:lang="en">Cell type. ENDOTHELIAL</xsd:documentation>
</xsd:annotation>
</xsd:element>
<xsd:element name="pdbx_gene_src_cell_line" minOccurs="0" maxOccurs="1" nillable="true" type="xsd:string">
<xsd:annotation>
<xsd:documentation xml:lang="en">The specific line of cells. HELA CELLS</xsd:documentation>
</xsd:annotation>
</xsd:element>
<xsd:element name="pdbx_gene_src_cellular_location" minOccurs="0" maxOccurs="1" nillable="true" type="xsd:string">
<xsd:annotation>
<xsd:documentation xml:lang="en">Identifies the location inside (or outside) the cell. CYTOPLASM NUCLEUS</xsd:documentation>
</xsd:annotation>
</xsd:element>
<xsd:element name="pdbx_gene_src_fragment" minOccurs="0" maxOccurs="1" nillable="true" type="xsd:string">
<xsd:annotation>
<xsd:documentation xml:lang="en">A domain or fragment of the molecule. CYTOPLASM NUCLEUS</xsd:documentation>
</xsd:annotation>
</xsd:element>
<xsd:element name="pdbx_gene_src_gene" minOccurs="0" maxOccurs="1" nillable="true" type="xsd:string">
<xsd:annotation>
<xsd:documentation xml:lang="en">Identifies the gene.</xsd:documentation>
</xsd:annotation>
</xsd:element>
<xsd:element name="pdbx_gene_src_ncbi_taxonomy_id" minOccurs="0" maxOccurs="1" nillable="true" type="xsd:string">
<xsd:annotation>
<xsd:documentation xml:lang="en">NCBI Taxonomy identifier for the gene source organism. Reference: Wheeler DL, Chappey C, Lash AE, Leipe DD, Madden TL, Schuler GD, Tatusova TA, Rapp BA (2000). Database resources of the National Center for Biotechnology Information. Nucleic Acids Res 2000 Jan 1;28(1):10-4 Benson DA, Karsch-Mizrachi I, Lipman DJ, Ostell J, Rapp BA, Wheeler DL (2000). GenBank. Nucleic Acids Res 2000 Jan 1;28(1):15-18.</xsd:documentation>
</xsd:annotation>
</xsd:element>
<xsd:element name="pdbx_gene_src_organ" minOccurs="0" maxOccurs="1" nillable="true" type="xsd:string">
<xsd:annotation>
<xsd:documentation xml:lang="en">Organized group of tissues that carries on a specialized function. KIDNEY LIVER PANCREAS</xsd:documentation>
</xsd:annotation>
</xsd:element>
<xsd:element name="pdbx_gene_src_organelle" minOccurs="0" maxOccurs="1" nillable="true" type="xsd:string">
<xsd:annotation>
<xsd:documentation xml:lang="en">Organized structure within cell. MITOCHONDRIA</xsd:documentation>
</xsd:annotation>
</xsd:element>
<xsd:element name="pdbx_gene_src_plasmid" minOccurs="0" maxOccurs="1" nillable="true" type="xsd:string">
<xsd:annotation>
<xsd:documentation xml:lang="en">The source plasmid.</xsd:documentation>
</xsd:annotation>
</xsd:element>
<xsd:element name="pdbx_gene_src_plasmid_name" minOccurs="0" maxOccurs="1" nillable="true" type="xsd:string">
<xsd:annotation>
<xsd:documentation xml:lang="en">The source plasmid.</xsd:documentation>
</xsd:annotation>
</xsd:element>
<xsd:element name="pdbx_gene_src_scientific_name" minOccurs="0" maxOccurs="1" nillable="true" type="xsd:string">
<xsd:annotation>
<xsd:documentation xml:lang="en">Scientific name of the organism. ESCHERICHIA COLI HOMO SAPIENS SACCHAROMYCES CEREVISIAE</xsd:documentation>
</xsd:annotation>
</xsd:element>
<xsd:element name="pdbx_gene_src_variant" minOccurs="0" maxOccurs="1" nillable="true" type="xsd:string">
<xsd:annotation>
<xsd:documentation xml:lang="en">Identifies the variant. DELTAH1DELTATRP</xsd:documentation>
</xsd:annotation>
</xsd:element>
<xsd:element name="pdbx_host_org_atcc" minOccurs="0" maxOccurs="1" nillable="true" type="xsd:string">
<xsd:annotation>
<xsd:documentation xml:lang="en">Americal Tissue Culture Collection of the expression system. Where full details of the protein production are available it would be expected that this item would be derived from attribute host_org_culture_collection in category entity_src_gen_express</xsd:documentation>
</xsd:annotation>
</xsd:element>
<xsd:element name="pdbx_host_org_cell" minOccurs="0" maxOccurs="1" nillable="true" type="xsd:string">
<xsd:annotation>
<xsd:documentation xml:lang="en">Cell type from which the gene is derived. Where entity.target_id is provided this should be derived from details of the target. ENDOTHELIAL</xsd:documentation>
</xsd:annotation>
</xsd:element>
<xsd:element name="pdbx_host_org_cell_line" minOccurs="0" maxOccurs="1" nillable="true" type="xsd:string">
<xsd:annotation>
<xsd:documentation xml:lang="en">A specific line of cells used as the expression system. Where full details of the protein production are available it would be expected that this item would be derived from entity_src_gen_express.host_org_cell_line HELA</xsd:documentation>
</xsd:annotation>
</xsd:element>
<xsd:element name="pdbx_host_org_cellular_location" minOccurs="0" maxOccurs="1" nillable="true" type="xsd:string">
<xsd:annotation>
<xsd:documentation xml:lang="en">Identifies the location inside (or outside) the cell which expressed the molecule. CYTOPLASM NUCLEUS</xsd:documentation>
</xsd:annotation>
</xsd:element>
<xsd:element name="pdbx_host_org_culture_collection" minOccurs="0" maxOccurs="1" nillable="true" type="xsd:string">
<xsd:annotation>
<xsd:documentation xml:lang="en">Culture collection of the expression system. Where full details of the protein production are available it would be expected that this item would be derived somehwere, but exactly where is not clear.</xsd:documentation>
</xsd:annotation>
</xsd:element>
<xsd:element name="pdbx_host_org_gene" minOccurs="0" maxOccurs="1" nillable="true" type="xsd:string">
<xsd:annotation>
<xsd:documentation xml:lang="en">Specific gene which expressed the molecule. HIV-1 POL GLNS7 U1A (2-98, Y31H, Q36R)</xsd:documentation>
</xsd:annotation>
</xsd:element>
<xsd:element name="pdbx_host_org_ncbi_taxonomy_id" minOccurs="0" maxOccurs="1" nillable="true" type="xsd:string">
<xsd:annotation>
<xsd:documentation xml:lang="en">NCBI Taxonomy identifier for the expression system organism. Reference: Wheeler DL, Chappey C, Lash AE, Leipe DD, Madden TL, Schuler GD, Tatusova TA, Rapp BA (2000). Database resources of the National Center for Biotechnology Information. Nucleic Acids Res 2000 Jan 1;28(1):10-4 Benson DA, Karsch-Mizrachi I, Lipman DJ, Ostell J, Rapp BA, Wheeler DL (2000). GenBank. Nucleic Acids Res 2000 Jan 1;28(1):15-18.</xsd:documentation>
</xsd:annotation>
</xsd:element>
<xsd:element name="pdbx_host_org_organ" minOccurs="0" maxOccurs="1" nillable="true" type="xsd:string">
<xsd:annotation>
<xsd:documentation xml:lang="en">Specific organ which expressed the molecule. KIDNEY</xsd:documentation>
</xsd:annotation>
</xsd:element>
<xsd:element name="pdbx_host_org_organelle" minOccurs="0" maxOccurs="1" nillable="true" type="xsd:string">
<xsd:annotation>
<xsd:documentation xml:lang="en">Specific organelle which expressed the molecule. MITOCHONDRIA</xsd:documentation>
</xsd:annotation>
</xsd:element>
<xsd:element name="pdbx_host_org_scientific_name" minOccurs="0" maxOccurs="1" nillable="true" type="xsd:string">
<xsd:annotation>
<xsd:documentation xml:lang="en">The scientific name of the organism that served as host for the production of the entity. Where full details of the protein production are available it would be expected that this item would be derived from attribute host_org_scientific_name in category entity_src_gen_express or via attribute host_org_tax_id in category entity_src_gen_express ESCHERICHIA COLI SACCHAROMYCES CEREVISIAE</xsd:documentation>
</xsd:annotation>
</xsd:element>
<xsd:element name="pdbx_host_org_strain" minOccurs="0" maxOccurs="1" nillable="true" type="xsd:string">
<xsd:annotation>
<xsd:documentation xml:lang="en">The strain of the organism in which the entity was expressed. AR120</xsd:documentation>
</xsd:annotation>
</xsd:element>
<xsd:element name="pdbx_host_org_tissue" minOccurs="0" maxOccurs="1" nillable="true" type="xsd:string">
<xsd:annotation>
<xsd:documentation xml:lang="en">The specific tissue which expressed the molecule. Where full details of the protein production are available it would be expected that this item would be derived from attribute host_org_tissue in category entity_src_gen_express heart liver eye lens</xsd:documentation>
</xsd:annotation>
</xsd:element>
<xsd:element name="pdbx_host_org_tissue_fraction" minOccurs="0" maxOccurs="1" nillable="true" type="xsd:string">
<xsd:annotation>
<xsd:documentation xml:lang="en">The fraction of the tissue which expressed the molecule. mitochondria nucleus membrane</xsd:documentation>
</xsd:annotation>
</xsd:element>
<xsd:element name="pdbx_host_org_variant" minOccurs="0" maxOccurs="1" nillable="true" type="xsd:string">
<xsd:annotation>
<xsd:documentation xml:lang="en">Variant of the organism used as the expression system. Where full details of the protein production are available it would be expected that this item be derived from entity_src_gen_express.host_org_variant or via attribute host_org_tax_id in category entity_src_gen_express TRP-LAC LAMBDA DE3</xsd:documentation>
</xsd:annotation>
</xsd:element>
<xsd:element name="pdbx_host_org_vector" minOccurs="0" maxOccurs="1" nillable="true" type="xsd:string">
<xsd:annotation>
<xsd:documentation xml:lang="en">Identifies the vector used. Where full details of the protein production are available it would be expected that this item would be derived from attribute vector_name in category entity_src_gen_clone. PBIT36 PET15B PUC18</xsd:documentation>
</xsd:annotation>
</xsd:element>
<xsd:element name="pdbx_host_org_vector_type" minOccurs="0" maxOccurs="1" nillable="true" type="xsd:string">
<xsd:annotation>
<xsd:documentation xml:lang="en">Identifies the type of vector used (plasmid, virus, or cosmid). Where full details of the protein production are available it would be expected that this item would be derived from attribute vector_type in category entity_src_gen_express. COSMID PLASMID</xsd:documentation>
</xsd:annotation>
</xsd:element>
<xsd:element name="pdbx_seq_type" minOccurs="0" maxOccurs="1" nillable="true">
<xsd:annotation>
<xsd:documentation xml:lang="en">This data item povides additional information about the sequence type.</xsd:documentation>
</xsd:annotation>
<xsd:simpleType>
<xsd:restriction base="xsd:string">
<xsd:enumeration value="N-terminal tag"/>
<xsd:enumeration value="C-terminal tag"/>
<xsd:enumeration value="Biological sequence"/>
<xsd:enumeration value="Linker"/>
</xsd:restriction>
</xsd:simpleType>
</xsd:element>
<xsd:element name="plasmid_details" minOccurs="0" maxOccurs="1" nillable="true" type="xsd:string">
<xsd:annotation>
<xsd:documentation xml:lang="en">A description of special aspects of the plasmid that produced the entity in the host organism. Where full details of the protein production are available it would be expected that this item would be derived from attribute details in category pdbx_construct of the construct pointed to from attribute plasmid_id in category entity_src_gen_express.</xsd:documentation>
</xsd:annotation>
</xsd:element>
<xsd:element name="plasmid_name" minOccurs="0" maxOccurs="1" nillable="true" type="xsd:string">
<xsd:annotation>
<xsd:documentation xml:lang="en">The name of the plasmid that produced the entity in the host organism. Where full details of the protein production are available it would be expected that this item would be derived from attribute name in category pdbx_construct of the construct pointed to from attribute plasmid_id in category entity_src_gen_express. pET3C pT123sab</xsd:documentation>
</xsd:annotation>
</xsd:element>
<xsd:element name="start_construct_id" minOccurs="0" maxOccurs="1" nillable="true" type="xsd:string">
<xsd:annotation>
<xsd:documentation xml:lang="en">A pointer to attribute id in category pdbx_construct in the PDBX_CONSTRUCT category. The indentified sequence is the initial construct.</xsd:documentation>
</xsd:annotation>
</xsd:element>
</xsd:all>
<xsd:attribute name="entity_id" use="required" type="xsd:string">
<xsd:annotation>
<xsd:documentation xml:lang="en">This data item is a pointer to attribute id in category entity in the ENTITY category.</xsd:documentation>
</xsd:annotation>
</xsd:attribute>
<xsd:attribute name="pdbx_src_id" use="required" type="xsd:integer">
<xsd:annotation>
<xsd:documentation xml:lang="en">This data item is an ordinal identifier for entity_src_gen data records.</xsd:documentation>
</xsd:annotation>
</xsd:attribute>
</xsd:complexType>
</xsd:element>
</xsd:sequence>
</xsd:complexType> |